Synthesis of biomimetic nanoparticulate materials using a microfluidic platform and investigation of their interaction with cells

GACR Junior project

project no: GJ17-11851Y
duration: 3 years (1.1.2017 – 31.12.2019)

The vast advances in medicine and biology in the last half of a century reached a level of detail and understanding that allow not only the identification and characterization of human diseases and medical conditions, but also, potentially, their specificity for each and every patient. These two interrelated developments, in medicine and instrumentation, respectively, open the opportunity that in the near future the treatment of diseases will take the form of personalized medicine. The present project proposes the development of a microfluidic reactor for the controlled synthesis of nanoparticles, tailored to specific applications in cancer treatment, at short notice, and in sufficient quantities. The process based on microfluidics systems will greatly increase the effectiveness of nanoparticle production, decrease the unwanted by-products, as well as save time compared to standard chemical procedures. The project outcomes could constitute a pathway for personalized medicine, as in the future, many diagnostic, therapeutic, and theranostic treatments will be based on nanoparticles.

The main goal of the project is to develop and optimize a microfluidic reactor device, which can deliver, on command, with high-reproducibility and high size-accuracy, in a one-step process, small batches of nanoparticles tailored for cancer treatment of specific patients.

Development of biomimetic particles for antibacterial applications

Funding programme for applied research ZETA

PID: TJ01000313
duration: 2 years (1.1.2018 – 31.12.2019)

Bacterial infections cause more deaths per year than cancer and heart disease combined. The goal of the project is to develop a drug carrier – so-called artificial garlic cells – which will use natural antibacterial substances found in garlic and related Allium plants in commercial applications such as antibacterial creams and powders for the treatment of mycoses and inflammations, or sanitation of surfaces.

Within two years, our goal is to develop and optimize the process for the preparation of biocompatible carriers of precursors of highly reactive substances with antibacterial activity. Since the half-life of such substances is in the order of minutes since they originated, bacteria do not have the time to develop resistance in contrast to relatively stable synthetic antibiotics.

NewSurf: New method of surface modification for enzymatic-free cell harvesting aimed for pharmacological and medical applications


PID: CZ.01.1.02/0.0/0.0/17_107/0012489
duration: 2 years (01.07.2018 – 31.10.2020)

In co-operation with PrimeCell Therapeutics Inc.

NewSurf project is focused on the development and testing of novel polymer coating sensitive to the electromagnetic field. A sudden change of surface properties will induce detachment of adhered cells. No need for additional chemicals or enzymes commonly used for cell detachment means lower stress for collected cells, minimal risk of cell destruction, higher yields and more straightforward cell application without the necessity of additional purification.

The expected outcome of this project will be a new system improving the currently used methods for cultivation and harvesting of stem cells.